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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Proximal renal tubular acidosis ： ウィキペディア英語版 Proximal renal tubular acidosis Proximal renal tubular acidosis (pRTA) or Type 2 Renal tubular acidosis (RTA) is a type of RTA caused by a failure of the proximal tubular cells to reabsorb filtered bicarbonate from the urine, leading to urinary bicarbonate wasting and subsequent acidemia. The distal intercalated cells function normally, so the acidemia is less severe than dRTA and the urine can acidify to a pH of less than 5.3. pRTA also has several causes, and may occasionally be present as a solitary defect, but is usually associated with a more generalised dysfunction of the proximal tubular cells called Fanconi syndrome where there is also phosphaturia, glycosuria, aminoaciduria, uricosuria and tubular proteinuria. The principal feature of Fanconi syndrome is bone demineralization (osteomalacia or rickets) due to phosphate wasting. ==Causes== Familial disorders *Cystinosis *Galactosemia *Glycogen storage disease (type I) *Hereditary fructose intolerance *Lowe syndrome *Tyrosinemia *Wilson's disease〔 〕 Acquired disorders *Amyloidosis *Multiple myeloma *Paroxysmal nocturnal hemoglobinuria *Toxins, such as HAART, ifosfamide, lead, and cadmium 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Proximal renal tubular acidosis」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.